Essential Role of LFA-1 in Activating Th2-Like Responses by α-Galactosylceramide-Activated NKT Cells | Zendy

Goichi Matsumoto | Zendy; Eiro Kubota | Zendy; Yasushi Omi | Zendy; Ushaku Lee | Zendy; Josef Penninger | Zendy

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Essential Role of LFA-1 in Activating Th2-Like Responses by α-Galactosylceramide-Activated NKT Cells

Author(s) -

Goichi Matsumoto,

Eiro Kubota,

Yasushi Omi,

Ushaku Lee,

Josef Penninger

Publication year - 2004

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.173.8.4976

Subject(s) - natural killer t cell , lymphocyte function associated antigen 1 , microbiology and biotechnology , stimulation , receptor , biology , cell adhesion molecule , immunology , chemistry , t cell , immune system , endocrinology , biochemistry , intercellular adhesion molecule 1

NKT cells produce large amounts of cytokines associated with both the Th1 (IFN-gamma) and Th2 (IL-4) responses following stimulation of their invariant Valpha14 Ag receptor. The role of adhesion molecules in the activation of NKT cells by the Valpha14 ligand alpha-galactosylceramide (alpha-GalCer) remains unclear. To address this issue, LFA-1-/- (CD11a-/-) mice were used to investigate IL-4 and IFN-gamma production by NKT cells following alpha-GalCer stimulation. Intriguingly, LFA-1-/- mice showed increased IL-4, IL-5, and IL-13 production and polarized Th2-type responses in response to alpha-GalCer in vitro and in vivo. Furthermore, the Th2-specific transcription factor GATA-3 was up-regulated in alpha-GalCer-activated NKT cells from LFA-1-/- mice. These results provide the first genetic evidence that the adhesion receptor LFA-1 has a crucial role in Th2-polarizing functions of NKT cells.

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