A Structural Basis for the Association of DAP12 with Mouse, but Not Human, NKG2D | Zendy

David B. Rosen | Zendy; M. Araki | Zendy; Jessica A. Hamerman | Zendy; Tai-An Chen | Zendy; Takashi Yamamura | Zendy; Lewis L. Lanier | Zendy

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A Structural Basis for the Association of DAP12 with Mouse, but Not Human, NKG2D

Author(s) -

David B. Rosen,

M. Araki,

Jessica A. Hamerman,

Tai-An Chen,

Takashi Yamamura,

Lewis L. Lanier

Publication year - 2004

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.173.4.2470

Subject(s) - nkg2d , transmembrane protein , receptor , signal transduction , signal transducing adaptor protein , biology , immune system , microbiology and biotechnology , immunology , genetics , cytotoxic t cell , in vitro

Prior studies have revealed that alternative mRNA splicing of the mouse NKG2D gene generates receptors that associate with either the DAP10 or DAP12 transmembrane adapter signaling proteins. We report that NKG2D function is normal in human patients lacking functional DAP12, indicating that DAP10 is sufficient for human NKG2D signal transduction. Further, we show that human NKG2D is incapable of associating with DAP12 and provide evidence that structural differences in the transmembrane of mouse and human NKG2D account for the species-specific difference for this immune receptor.

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