Human Thymus Exports Naive CD8 T Cells That Can Home to Nonlymphoid Tissues | Zendy

Alfred Zippelius | Zendy; Gilles Bioley | Zendy; FrédériqueAnne Le Gal | Zendy; Nathalie Rufer | Zendy; Marlène Brandes | Zendy; Pascal Batard | Zendy; Magda De Smedt | Zendy; Jean Plum | Zendy; Daniel E. Speiser | Zendy; JeanCharles Cerottini | Zendy; PierreYves Dietrich | Zendy; Pedro Romero | Zendy; Mikaël J. Pittet | Zendy

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Human Thymus Exports Naive CD8 T Cells That Can Home to Nonlymphoid Tissues

Author(s) -

Alfred Zippelius,

Gilles Bioley,

FrédériqueAnne Le Gal,

Nathalie Rufer,

Marlène Brandes,

Pascal Batard,

Magda De Smedt,

Jean Plum,

Daniel E. Speiser,

JeanCharles Cerottini,

PierreYves Dietrich,

Pedro Romero,

Mikaël J. Pittet

Publication year - 2004

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.172.5.2773

Subject(s) - cd8 , biology , cytotoxic t cell , immunology , homing (biology) , microbiology and biotechnology , naive t cell , lymphocyte homing receptor , c c chemokine receptor type 7 , t cell , antigen , t cell receptor , cell , immune system , chemokine , in vitro , cell adhesion , genetics , ecology , chemokine receptor

Functionally naive CD8 T cells in peripheral blood from adult humans can be fully described by their CD45RA(bright)CCR7(+)CD62L(+) cell surface phenotype. Cord blood lymphocytes, from healthy newborns, are homogenously functionally naive. Accordingly, the majority of cord blood CD8 T cells express the same pattern of cell surface molecules. Unexpectedly, however, a significant fraction of cord blood CD8 T cells express neither CCR7 nor CD62L. Yet these cells remain functionally naive as they contain high levels of TCR excision circles, have long telomeres, display highly polyclonal TCRs, and do not exhibit immediate effector functions. In addition, these CD8 T cells already represent a significant fraction of the mature naive CD8 single-positive thymocyte repertoire and may selectively express the cutaneous lymphocyte Ag. We suggest that CD8 single-positive thymocytes comprise two pools of naive precursors that exhibit distinct homing properties. Once seeded in the periphery, naive CCR7(+)CD62L(+) CD8 T cells patrol secondary lymphoid organs, whereas naive CCR7(-)CD62L(-) CD8 T cells selectively migrate to peripheral tissues such as skin.

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