Reduced Thymocyte Development in Sonic Hedgehog Knockout Embryos | Zendy

Divya Shah | Zendy; Ariadne L. Hager-Theodorides | Zendy; Susan V. Outram | Zendy; Susan Ross | Zendy; Alberto Varas | Zendy; Tessa Crompton | Zendy

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Reduced Thymocyte Development in Sonic Hedgehog Knockout Embryos

Author(s) -

Divya Shah,

Ariadne L. Hager-Theodorides,

Susan V. Outram,

Susan Ross,

Alberto Varas,

Tessa Crompton

Publication year - 2004

Publication title -

the journal of immunology

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.172.4.2296

Subject(s) - sonic hedgehog , thymocyte , biology , cd8 , hedgehog , cd44 , population , microbiology and biotechnology , embryo , double negative , immunology , cell , genetics , signal transduction , immune system , medicine , environmental health

The Hedgehog family of secreted intercellular signaling molecules are regulators of patterning and organogenesis during animal development. In this study we provide genetic evidence that Sonic Hedgehog (Shh) has a role in the control of murine T cell development. Analysis of Shh(-/-) mouse embryos revealed that Shh regulates fetal thymus cellularity and thymocyte differentiation. Shh is necessary for expansion of CD4(-)CD8(-) double-negative (DN) thymocytes and for efficient transition from the earliest CD44(+)CD25(-) DN population to the subsequent CD44(+)CD25(+) DN population and from DN to CD4(+)CD8(+) double-positive cells.

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