BCL-6 Mutations in Pulmonary Lymphoproliferative Disorders: Demonstration of an Aberrant Immunological Reaction in HIV-Related Lymphoid Interstitial Pneumonia | Zendy

Katsushi Kurosu | Zendy; Michael D. Weiden | Zendy; Yuichi Takiguchi | Zendy; William N. Rom | Zendy; Norio Yumoto | Zendy; Jaishree Jagirdar | Zendy; Koh Nakata | Zendy; Yasunori Kasahara | Zendy; Nobuhiro Tanabe | Zendy; Koichiro Tatsumi | Zendy; Atsuo Mikata | Zendy; Takayuki Kuriyama | Zendy

Open Access

BCL-6 Mutations in Pulmonary Lymphoproliferative Disorders: Demonstration of an Aberrant Immunological Reaction in HIV-Related Lymphoid Interstitial Pneumonia

Author(s) -

Katsushi Kurosu,

Michael D. Weiden,

Yuichi Takiguchi,

William N. Rom,

Norio Yumoto,

Jaishree Jagirdar,

Koh Nakata,

Yasunori Kasahara,

Nobuhiro Tanabe,

Koichiro Tatsumi,

Atsuo Mikata,

Takayuki Kuriyama

Publication year - 2004

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.172.11.7116

Subject(s) - somatic hypermutation , lymphoproliferative disorders , biology , germinal center , malt lymphoma , lymphoma , transversion , marginal zone , mutation , lymphatic system , gene , cancer research , immunology , virology , genetics , b cell , antibody

We used a PCR and sequence procedure to analyze the Ig V(H) gene and the mutations in the 5' regulatory regions of BCL-6 genes in pulmonary lymphoproliferative disorders (mucosa-associated lymphoid tissue (MALT) lymphoma, HIV-related, EBV-related, and virus-negative lymphocytic interstitial pneumonia (LIP)). Eight of 20 (40%) pulmonary MALT lymphoma and 10 of 20 LIP (5 of 5 (100%) HIV-related, 2 of 5 (40%) EBV-related, and 3 of 10 (30%) virus-negative LIP) cases showed BCL-6 gene mutations. Intraclonal heterogeneity of the BCL-6 mutations was observed only in pulmonary MALT lymphoma cases whose Ig V(H) genes also showed intraclonal heterogeneity. Ongoing BCL-6 mutations might reflect re-entry into a germinal center pathway to further mutations. BCL-6 mutations in pulmonary MALT lymphoma and HIV-negative LIP showed some features (high transition to transversion ratio, standard polarity, and RGYW/WRCY bias) of Ig V(H) gene hypermutation, leading to the view that pulmonary MALT lymphomas and HIV-negative LIP are under the influence of germinal center hypermutation mechanisms. Because BCL-6 mutations in HIV-related LIP cases did not demonstrate features of Ig V(H) gene hypermutation, immunological reactions in HIV-related LIP are the result of a process different from that found in HIV-negative pulmonary lymphoproliferative disorders.

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