NK Cell TRAIL Eliminates Immature Dendritic Cells In Vivo and Limits Dendritic Cell Vaccination Efficacy | Zendy

Yoshihiro Hayakawa | Zendy; Valentina Screpanti | Zendy; Hideo Yagita∥ | Zendy; Alf Grandien | Zendy; HansGustaf Ljunggren | Zendy; Mark J. Smyth | Zendy; Benedict J. Chambers | Zendy

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NK Cell TRAIL Eliminates Immature Dendritic Cells In Vivo and Limits Dendritic Cell Vaccination Efficacy

Author(s) -

Yoshihiro Hayakawa,

Valentina Screpanti,

Hideo Yagita∥,

Alf Grandien,

HansGustaf Ljunggren,

Mark J. Smyth,

Benedict J. Chambers

Publication year - 2004

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.172.1.123

Subject(s) - dendritic cell , in vivo , microbiology and biotechnology , immunization , immunology , biology , cell , in vitro , immune system , chemistry , biochemistry , genetics

Recent studies have implicated a possible role for NK cells in regulating dendritic cells (DC) in vitro. In the present study, we demonstrate that immature DC are rapidly eliminated by NK cells in vivo via a pathway dependent on the TNF-related apoptosis-inducing ligand (TRAIL). Elimination of NK cells and/or neutralization of TRAIL function during immunization with immature DC loaded with nonself or tumor Ags significantly enhanced T cell responses to these Ags and Ag-specific tumor immunity. These data suggested that NK cell TRAIL might regulate responses to vaccination by controlling the survival of Ag-loaded DC.

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