Virus Evasion of MHC Class I Molecule Presentation | Zendy

Jason L. Petersen | Zendy; Chantey R. Morris | Zendy; Joyce C. Solheim | Zendy

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Virus Evasion of MHC Class I Molecule Presentation

Author(s) -

Jason L. Petersen,

Chantey R. Morris,

Joyce C. Solheim

Publication year - 2003

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.171.9.4473

Subject(s) - mhc class i , endoplasmic reticulum , transporter associated with antigen processing , antigen presentation , major histocompatibility complex , antigen processing , mhc restriction , microbiology and biotechnology , chain (unit) , evasion (ethics) , cd74 , mhc class ii , chemistry , beta 2 microglobulin , heavy chain , biology , virology , antigen , immune system , biochemistry , immunology , t cell , gene , physics , astronomy

The MHC class I H chain and the L chain that assembles with it, β2-microglobulin (β2m),[3][1] are cotranslationally inserted into the lumen of the endoplasmic reticulum (ER) ([1][2]). In the ER, the MHC/β2m heterodimer binds peptide that is generated by proteasomal protein degradation in the

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