T/NK Bipotent Progenitors in the Thymus Retain the Potential to Generate Dendritic Cells | Zendy

Hui Qing Shen | Zendy; Min Lü | Zendy; Tomokatsu Ikawa | Zendy; Kyoko Masuda | Zendy; Koichiro Ohmura | Zendy; Nagahiro Minato | Zendy; Yoshimoto Katsura | Zendy; Hiroshi Kawamoto | Zendy

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T/NK Bipotent Progenitors in the Thymus Retain the Potential to Generate Dendritic Cells

Author(s) -

Hui Qing Shen,

Min Lü,

Tomokatsu Ikawa,

Kyoko Masuda,

Koichiro Ohmura,

Nagahiro Minato,

Yoshimoto Katsura,

Hiroshi Kawamoto

Publication year - 2003

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.171.7.3401

Subject(s) - progenitor cell , biology , microbiology and biotechnology , progenitor , il 2 receptor , immunology , dendritic cell , population , cd44 , t cell , stem cell , cell , immune system , medicine , genetics , environmental health

We have previously shown that the earliest thymic progenitors retain the potential to generate T and NK cells and that they lose the bipotentiality to give rise to unipotent T and NK progenitors during the progression of intrathymic developmental stages. The present study examines the ability of these thymic progenitors for generation of dendritic cells (DC) with a new clonal assay that is capable of determining the developmental potential for DC in addition to T cells and NK cells. We found that the large majority of the T/NK bipotential progenitors in the earliest population of fetal thymus was able to generate DC. Although the DC potential is lost with the progression of the differentiation stage, some of the T/NK bipotential progenitors still retain their DC potential even at the CD44(+)CD25(+) stage.

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