Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells | Zendy

Qizhi Tang | Zendy; Kammi Henriksen | Zendy; Elisa K. Boden | Zendy; Aaron J. Tooley | Zendy; Jianqin Ye | Zendy; Sumit K. Subudhi | Zendy; Xin Xiao Zheng | Zendy; Terry B. Strom | Zendy; Jeffrey A. Bluestone | Zendy

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Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells

Author(s) -

Qizhi Tang,

Kammi Henriksen,

Elisa K. Boden,

Aaron J. Tooley,

Jianqin Ye,

Sumit K. Subudhi,

Xin Xiao Zheng,

Terry B. Strom,

Jeffrey A. Bluestone

Publication year - 2003

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.171.7.3348

Subject(s) - cd28 , il 2 receptor , homeostasis , immunology , peripheral , biology , blockade , peripheral tolerance , microbiology and biotechnology , t cell , medicine , receptor , immune system , genetics

CD28/B7 blockade leads to exacerbated autoimmune disease in the nonobese diabetic mouse strain as a result of a marked reduction in the number of CD4(+)CD25(+) regulatory T cells (Tregs). Herein, we demonstrate that CD28 controls both thymic development and peripheral homeostasis of Tregs. CD28 maintains a stable pool of peripheral Tregs by both supporting their survival and promoting their self-renewal. CD28 engagement promotes survival by regulating IL-2 production by conventional T cells and CD25 expression on Tregs.

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