Cutting Edge: SR-PSOX/CXC Chemokine Ligand 16 Mediates Bacterial Phagocytosis by APCs Through its Chemokine Domain | Zendy

Takeshi Shimaoka | Zendy; Takashi Nakayama | Zendy; Noriaki Kume | Zendy; Shu Takahashi | Zendy; Junko Yamaguchi | Zendy; Manabu Minami | Zendy; Kazutaka Hayashida | Zendy; Toru Kita | Zendy; Jun Ohsumi | Zendy; Osamu Yoshie | Zendy; Shin Yonehara | Zendy

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Cutting Edge: SR-PSOX/CXC Chemokine Ligand 16 Mediates Bacterial Phagocytosis by APCs Through its Chemokine Domain

Author(s) -

Takeshi Shimaoka,

Takashi Nakayama,

Noriaki Kume,

Shu Takahashi,

Junko Yamaguchi,

Manabu Minami,

Kazutaka Hayashida,

Toru Kita,

Jun Ohsumi,

Osamu Yoshie,

Shin Yonehara

Publication year - 2003

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.171.4.1647

Subject(s) - cxcl16 , xcl2 , chemotaxis , ccl25 , chemokine , scavenger receptor , cxc chemokine receptors , microbiology and biotechnology , phagocytosis , cxcl2 , c c chemokine receptor type 6 , ccl21 , cc chemokine receptors , cxcl9 , chemokine receptor , chemistry , biology , receptor , immunology , inflammation , biochemistry , lipoprotein , cholesterol

SR-PSOX and CXC chemokine ligand (CXCL)16, which were originally identified as a scavenger receptor and a transmembrane-type chemokine, respectively, are indicated to be identical. In this study, we demonstrate that membrane-bound SR-PSOX/CXCL16 mediates adhesion and phagocytosis of both Gram-negative and Gram-positive bacteria. Importantly, our prepared anti-SR-PSOX mAb, which suppressed chemotactic activity of SR-PSOX, significantly inhibited bacterial phagocytosis by human APCs including dendritic cells. Various scavenger receptor ligands inhibited the bacterial phagocytosis of SR-PSOX. In addition, the recognition specificity for bacteria was determined by only the chemokine domain of SR-PSOX/CXCL16. Thus, SR-PSOX/CXCL16 may play an important role in facilitating uptake of various pathogens and chemotaxis of T and NKT cells by APCs through its chemokine domain.

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