The STAT3–IL-10–IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury | Zendy

Lara Campana | Zendy; Philip J. Starkey Lewis | Zendy; Antonella Pellicoro | Zendy; Rebecca L. Aucott | Zendy; Janet Man | Zendy; Eoghan O’Duibhir | Zendy; Sarah Mok | Zendy; Sofía Ferreira-González | Zendy; Eilidh Livingstone | Zendy; Stephen N. Greenhalgh | Zendy; Katherine L. Hull | Zendy; Timothy J. Kendall | Zendy; Douglas Vernimmen | Zendy; Neil C. Henderson | Zendy; Luke Boulter | Zendy; Christopher D. Gregory | Zendy; Yi Feng | Zendy; Stephen M. Anderton | Zendy; Stuart J. Forbes | Zendy; John P. Iredale | Zendy

Open Access

The STAT3–IL-10–IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury

Author(s) -

Lara Campana,

Philip J. Starkey Lewis,

Antonella Pellicoro,

Rebecca L. Aucott,

Janet Man,

Eoghan O’Duibhir,

Sarah Mok,

Sofía Ferreira-González,

Eilidh Livingstone,

Stephen N. Greenhalgh,

Katherine L. Hull,

Timothy J. Kendall,

Douglas Vernimmen,

Neil C. Henderson,

Luke Boulter,

Christopher D. Gregory,

Yi Feng,

Stephen M. Anderton,

Stuart J. Forbes,

John P. Iredale

Publication year - 2017

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.1701247

Subject(s) - efferocytosis , inflammation , macrophage , regulator , phagocytosis , proinflammatory cytokine , phenotype , microbiology and biotechnology , biology , liver injury , apoptosis , immunology , in vitro , genetics , gene , endocrinology

The disposal of apoptotic bodies by professional phagocytes is crucial to effective inflammation resolution. Our ability to improve the disposal of apoptotic bodies by professional phagocytes is impaired by a limited understanding of the molecular mechanisms that regulate the engulfment and digestion of the efferocytic cargo. Macrophages are professional phagocytes necessary for liver inflammation, fibrosis, and resolution, switching their phenotype from proinflammatory to restorative. Using sterile liver injury models, we show that the STAT3-IL-10-IL-6 axis is a positive regulator of macrophage efferocytosis, survival, and phenotypic conversion, directly linking debris engulfment to tissue repair.

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