A Subset of Toll-Like Receptor Ligands Induces Cross-presentation by Bone Marrow-Derived Dendritic Cells | Zendy

Sandip K. Datta | Zendy; Vanessa Redecke | Zendy; Kiley R. Prilliman | Zendy; Kenji Takabayashi | Zendy; Maripat Corr | Zendy; Thomas C. Tallant | Zendy; Joseph DiDonato | Zendy; Roman Dziarski | Zendy; Shizuo Akira | Zendy; Stephen P. Schoenberger | Zendy; Eyal Raz | Zendy

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A Subset of Toll-Like Receptor Ligands Induces Cross-presentation by Bone Marrow-Derived Dendritic Cells

Author(s) -

Sandip K. Datta,

Vanessa Redecke,

Kiley R. Prilliman,

Kenji Takabayashi,

Maripat Corr,

Thomas C. Tallant,

Joseph DiDonato,

Roman Dziarski,

Shizuo Akira,

Stephen P. Schoenberger,

Eyal Raz

Publication year - 2003

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.170.8.4102

Subject(s) - cross presentation , tlr9 , tlr3 , toll like receptor , dendritic cell , tlr7 , microbiology and biotechnology , immune system , endosome , antigen presentation , cpg oligodeoxynucleotide , receptor , acquired immune system , chemistry , biology , immunology , innate immune system , t cell , biochemistry , gene , gene expression , dna methylation

Dendritic cells (DCs) are capable of cross-presenting exogenous Ag to CD8(+) CTLs. Detection of microbial products by Toll-like receptors (TLRs) leads to activation of DCs and subsequent orchestration of an adaptive immune response. We hypothesized that microbial TLR ligands could activate DCs to cross-present Ag to CTLs. Using DCs and CTLs in an in vitro cross-presentation system, we show that a subset of microbial TLR ligands, namely ligands of TLR3 (poly(inosinic-cytidylic) acid) and TLR9 (immunostimulatory CpG DNA), induces cross-presentation. In contrast to presentation of Ag to CD4(+) T cells by immature DCs, TLR-induced cross-presentation is mediated by mature DCs, is independent of endosomal acidification, and relies on cytosolic Ag processing machinery.

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