Cutting Edge: Histamine Inhibits IFN-α Release from Plasmacytoid Dendritic Cells | Zendy

Alessandra Mazzoni | Zendy; Cynthia A. Leifer | Zendy; Gregory Mullen | Zendy; Margaret Kennedy | Zendy; Dennis M. Klinman | Zendy; David M. Segal | Zendy

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Cutting Edge: Histamine Inhibits IFN-α Release from Plasmacytoid Dendritic Cells

Author(s) -

Alessandra Mazzoni,

Cynthia A. Leifer,

Gregory Mullen,

Margaret Kennedy,

Dennis M. Klinman,

David M. Segal

Publication year - 2003

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.170.5.2269

Subject(s) - histamine , plasmacytoid dendritic cell , tlr9 , immunology , receptor , cytokine , microbiology and biotechnology , biology , dendritic cell , cpg oligodeoxynucleotide , tumor necrosis factor alpha , antigen , endocrinology , gene , gene expression , biochemistry , dna methylation

Plasmacytoid dendritic cells (DC) are professional APC and a major source of type I IFN following viral infection. We previously showed that histamine alters the cytokine profiles of maturing monocyte-derived DC resulting in a change from Th1 to Th2 in their T cell polarizing function. In this study, we show that human plasmacytoid DC, activated by either CpG oligodeoxynucleotides or viral infection, also respond to histamine through H2 receptors, leading to a marked down-regulation of IFN-alpha and TNF-alpha and a moderate switch in their capacity to polarize naive T cells. Our findings provide an explanation for low levels of type I IFN frequently observed in atopic individuals.

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