TNF-Related Apoptosis-Inducing Ligand Mediates Tumoricidal Activity of Human Monocytes Stimulated by Newcastle Disease Virus | Zendy

Birgit Washburn | Zendy; Markus A. Weigand | Zendy; Anne GrosseWilde | Zendy; Markus Janke | Zendy; Heiko Stahl | Zendy; Eva Rieser | Zendy; Martin R. Sprick | Zendy; Volker Schirrmacher | Zendy; Henning Walczak | Zendy

Open Access

TNF-Related Apoptosis-Inducing Ligand Mediates Tumoricidal Activity of Human Monocytes Stimulated by Newcastle Disease Virus

Author(s) -

Birgit Washburn,

Markus A. Weigand,

Anne GrosseWilde,

Markus Janke,

Heiko Stahl,

Eva Rieser,

Martin R. Sprick,

Volker Schirrmacher,

Henning Walczak

Publication year - 2003

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.170.4.1814

Subject(s) - newcastle disease , tumor necrosis factor alpha , virus , apoptosis , stimulation , virology , cytotoxicity , immunology , biology , cancer research , in vitro , biochemistry , neuroscience

The Newcastle disease virus (NDV) has antineoplastic and immunostimulatory properties, and it is currently clinically tested in anticancer therapy. However, the tumoricidal mechanisms of NDV tumor therapy are not fully understood. The results presented here demonstrate that NDV-stimulated human monocytes (Mphi) kill various human tumor cell lines and that this tumoricidal activity is mediated by TRAIL. In contrast to soluble TRAIL-R2-Fc, soluble CD95-Fc and TNF-R2-Fc showed only minimal blocking of the antitumor effect. TRAIL expression is induced on human Mphi after stimulation with NDV and UV-inactivated NDV. These results show that TRAIL induction on human Mphi after NDV stimulation is independent from viral replication and that TRAIL mediates the tumoricidal activity of NDV-stimulated human Mphi.

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