Cutting Edge: Tyk2 Is Required for the Induction and Nuclear Translocation of Daxx Which Regulates IFN-α-Induced Suppression of B Lymphocyte Formation | Zendy

Kazuya Shimoda | Zendy; Kenjirou Kamesaki | Zendy; Akihiko Numata | Zendy; Kenichi Aoki | Zendy; Tadashi Matsuda | Zendy; Kenji Oritani | Zendy; Sadafumi Tamiya | Zendy; Kouji Kato | Zendy; Ken Takase | Zendy; Rie Imamura | Zendy; Tetsuya Yamamoto | Zendy; Toshihiro Miyamoto | Zendy; Koji Nagafuji | Zendy; Hisashi Gondo | Zendy; Seiho Nagafuchi | Zendy; Kei-ichi Nakayama | Zendy; Mine Harada | Zendy

Open Access

Cutting Edge: Tyk2 Is Required for the Induction and Nuclear Translocation of Daxx Which Regulates IFN-α-Induced Suppression of B Lymphocyte Formation

Author(s) -

Kazuya Shimoda,

Kenjirou Kamesaki,

Akihiko Numata,

Kenichi Aoki,

Tadashi Matsuda,

Kenji Oritani,

Sadafumi Tamiya,

Kouji Kato,

Ken Takase,

Rie Imamura,

Tetsuya Yamamoto,

Toshihiro Miyamoto,

Koji Nagafuji,

Hisashi Gondo,

Seiho Nagafuchi,

Kei-ichi Nakayama,

Mine Harada

Publication year - 2002

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.169.9.4707

Subject(s) - death associated protein 6 , biology , microbiology and biotechnology , chromosomal translocation , lymphocyte , immunology , nuclear protein , transcription factor , genetics , gene

IFN-alpha inhibits B lymphocyte development, and the nuclear protein Daxx has been reported to be essential for this biological activity. We show in this study that IFN-alpha inhibits the clonal proliferation of B lymphocyte progenitors in response to IL-7 in wild-type, but not in tyk2-deficient, mice. In addition, the IFN-alpha-induced up-regulation and nuclear translocation of Daxx are completely abrogated in the absence of tyk2. Therefore, tyk2 is directly involved in IFN-alpha signaling for the induction and translocation of Daxx, which may result in B lymphocyte growth arrest and/or apoptosis.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research