Inhibition of Endogenous TGF-β During Experimental Osteoarthritis Prevents Osteophyte Formation and Impairs Cartilage Repair | Zendy

Alwin Scharstuhl | Zendy; Harrie L. Glansbeek | Zendy; Henk M. van Beuningen | Zendy; E.L. Vitters | Zendy; P.M. van der Kraan | Zendy; Wim B. van den Berg | Zendy

Open Access

Inhibition of Endogenous TGF-β During Experimental Osteoarthritis Prevents Osteophyte Formation and Impairs Cartilage Repair

Author(s) -

Alwin Scharstuhl,

Harrie L. Glansbeek,

Henk M. van Beuningen,

E.L. Vitters,

P.M. van der Kraan,

Wim B. van den Berg

Publication year - 2002

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.169.1.507

Subject(s) - cartilage , osteoarthritis , endogeny , proteoglycan , transforming growth factor beta , transforming growth factor , articular cartilage , chemistry , microbiology and biotechnology , tgf beta 1 , medicine , pathology , anatomy , biology , biochemistry , alternative medicine

Osteoarthritis has as main characteristics the degradation of articular cartilage and the formation of new bone at the joint edges, so-called osteophytes. In this study enhanced expression of TGF-beta1 and -beta3 was detected in developing osteophytes and articular cartilage during murine experimental osteoarthritis. To determine the role of endogenous TGF-beta on osteophyte formation and articular cartilage, TGF-beta activity was blocked via a scavenging soluble TGF-beta-RII. Our results clearly show that inhibition of endogenous TGF-beta nearly completely prevented osteophyte formation. In contrast, treatment with recombinant soluble TGF-beta-RII markedly enhanced articular cartilage proteoglycan loss and reduced the thickness of articular cartilage. In conclusion, we show for the first time that endogenous TGF-beta is a crucial factor in the process of osteophyte formation and has an important function in protection against cartilage loss.

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