Positive Effects of Glucocorticoids on T Cell Function by Up-Regulation of IL-7 Receptor α | Zendy

Denis Franchimont | Zendy; Jérôme Galon | Zendy; Melanie S. Vacchio | Zendy; Samuel Fan | Zendy; Roberta Visconti | Zendy; David M. Frucht | Zendy; Vincent Geenen | Zendy; George P. Chrousos | Zendy; Jonathan D. Ashwell | Zendy; John J. O’Shea | Zendy

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Positive Effects of Glucocorticoids on T Cell Function by Up-Regulation of IL-7 Receptor α

Author(s) -

Denis Franchimont,

Jérôme Galon,

Melanie S. Vacchio,

Samuel Fan,

Roberta Visconti,

David M. Frucht,

Vincent Geenen,

George P. Chrousos,

Jonathan D. Ashwell,

John J. O’Shea

Publication year - 2002

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.168.5.2212

Subject(s) - glucocorticoid , glucocorticoid receptor , t cell receptor , function (biology) , immune system , receptor , signal transduction , biology , t cell , gene , gene expression , peripheral blood mononuclear cell , microbiology and biotechnology , apoptosis , endocrinology , medicine , immunology , genetics , in vitro

Despite the effects of glucocorticoids on immune function, relatively little is known about glucocorticoid-inducible genes and how their products may regulate lymphocyte function. Using DNA microarray technology to analyze gene expression in PBMC from healthy donors, we identified IL-7Ralpha as a glucocorticoid-inducible gene. This observation was confirmed at the mRNA and protein levels. Conversely, TCR signaling decreased IL-7Ralpha expression, and the relative strength of signaling between these two receptors determined the final IL-7Ralpha levels. The up-regulation of IL-7Ralpha by glucocorticoids was associated with enhanced IL-7-mediated signaling and function. Moreover, IL-7-mediated inhibition of apoptosis at increasing concentrations of glucocorticoids is consistent with enhanced cell sensitivity to IL-7 following glucocorticoid exposure. These observations provide a mechanism by which glucocorticoids may have a positive influence on T cell survival and function.

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