Cutting Edge: Inducible Costimulator Protein Regulates Both Th1 and Th2 Responses to Cutaneous Leishmaniasis | Zendy

Rebecca J. Greenwald | Zendy; Alexander J. McAdam | Zendy; Diane van der Woude | Zendy; Abhay R. Satoskar | Zendy; Arlene H. Sharpe | Zendy

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Cutting Edge: Inducible Costimulator Protein Regulates Both Th1 and Th2 Responses to Cutaneous Leishmaniasis

Author(s) -

Rebecca J. Greenwald,

Alexander J. McAdam,

Diane van der Woude,

Abhay R. Satoskar,

Arlene H. Sharpe

Publication year - 2002

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.168.3.991

Subject(s) - enhanced data rates for gsm evolution , cutaneous leishmaniasis , leishmaniasis , immunology , medicine , computer science , telecommunications

The CD28 family member inducible costimulator protein (ICOS) has an important role in T cell differentiation and Ig class switching. To investigate the role of ICOS in vivo, ICOS-/- mice were infected s.c. with Leishmania mexicana. While wild-type mice developed large, cutaneous lesions, the growth of lesions and tissue histopathology was significantly delayed in ICOS-/- mice. ICOS-/- mice exhibited marked decreases in both Th1 and Th2 cytokine production and profound defects in L. mexicana-specific Ig isotype class switching to IgG1 and IgG2a and reduced total IgE levels. Our findings indicate that ICOS is a key regulator of both Th1 and Th2 responses and has a role in controlling cutaneous L. mexicana infection.

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