Cutting Edge: Th2 Response Induction by Dendritic Cells: A Role for CD40 | Zendy

Andrew S. MacDonald | Zendy; Amy D. Straw | Zendy; Nicole M. Dalton | Zendy; Edward J. Pearce | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Cutting Edge: Th2 Response Induction by Dendritic Cells: A Role for CD40

Author(s) -

Andrew S. MacDonald,

Amy D. Straw,

Nicole M. Dalton,

Edward J. Pearce

Publication year - 2002

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.168.2.537

Subject(s) - cd40 , enhanced data rates for gsm evolution , microbiology and biotechnology , biology , psychology , computer science , genetics , cytotoxic t cell , telecommunications , in vitro

We investigated the influence of dendritic cell (DC) CD40 expression on Th2 and Th1 development by in vivo transfer of Ag-pulsed bone marrow-derived DC generated from wild-type (WT) or CD40(-/-) mice. Contrary to expectation, CD40(-/-) DC primed with Ag that inherently induce a Th2 response (soluble egg Ag from Schistosoma mansoni) failed to induce a Th2 response or any compensatory Th1 response, whereas CD40(-/-)DC primed with Ag that inherently induce a Th1 response (Propionibacterium acnes) generated a competent Th1 response. Thus, DC expression of CD40 is a prerequisite for initiation of Th2, but not Th1, responses by these Ag. Consistent with this, CD154(-/-) mice, unlike WT mice, failed to mount a Th2 response when directly injected with schistosome eggs but mounted a normal Th1 response after challenge with P. acnes. CD40-CD154 interaction can therefore play a major role in Th2 response induction.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research