Cutting Edge: IL-17F, a Novel Cytokine Selectively Expressed in Activated T Cells and Monocytes, Regulates Angiogenesis and Endothelial Cell Cytokine Production | Zendy

Trevor Starnes | Zendy; Michael J. Robertson | Zendy; George W. Sledge | Zendy; Stephanie L. Kelich | Zendy; Harikrishkshatri | Zendy; Hal E. Broxmeyer | Zendy; Robert Hromas | Zendy

Open Access

Cutting Edge: IL-17F, a Novel Cytokine Selectively Expressed in Activated T Cells and Monocytes, Regulates Angiogenesis and Endothelial Cell Cytokine Production

Author(s) -

Trevor Starnes,

Michael J. Robertson,

George W. Sledge,

Stephanie L. Kelich,

Harikrishkshatri,

Hal E. Broxmeyer,

Robert Hromas

Publication year - 2001

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.167.8.4137

Subject(s) - cytokine , angiogenesis , haematopoiesis , microbiology and biotechnology , monocyte , biology , immunology , cancer research , stem cell

A novel secreted cytokine, termed IL-17F, was cloned using nested RACE PCR. This cytokine bears homology to IL-17. IL-17F was expressed only in activated CD4(+) T cells and activated monocytes. Recombinant human IL-17F did not stimulate the proliferation of hematopoietic progenitors or the migration of mature leukocytes. However, it markedly inhibited the angiogenesis of human endothelial cells and induced endothelial cells to produce IL-2, TGF-beta, and monocyte chemoattractant protein-1.

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