Progressive Depletion of Peripheral B Lymphocytes in 4-1BB (CD137) Ligand/I-Eα-Transgenic Mice | Zendy

Gefeng Zhu | Zendy; Dallas B. Flies | Zendy; Koji Tamada | Zendy; Yonglian Sun | Zendy; Moses Rodriguez | Zendy; YangXin Fu | Zendy; Lieping Chen | Zendy

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Progressive Depletion of Peripheral B Lymphocytes in 4-1BB (CD137) Ligand/I-Eα-Transgenic Mice

Author(s) -

Gefeng Zhu,

Dallas B. Flies,

Koji Tamada,

Yonglian Sun,

Moses Rodriguez,

YangXin Fu,

Lieping Chen

Publication year - 2001

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.167.5.2671

Subject(s) - cd137 , biology , immune system , ctl* , genetically modified mouse , microbiology and biotechnology , transgene , immunology , splenocyte , humoral immunity , t cell , cd8 , gene , genetics

Interaction of 4-1BB (CD137) and its ligand (4-1BBL) is thought to positively regulate cell-mediated and humoral immune responses. We have prepared transgenic mouse strains that express 4-1BBL cDNA under the control of MHC class II I-Ealpha promoter. The 4-1BBL-transgenic mice show progressive splenomegaly and selective depletion of B220(+) B cells accompanied with low levels of circulating IgG and defective humoral responses to Ag challenge. In addition, splenocytes from the transgenic mice fail to provide stimulation for allogeneic T cells in both lymphoproliferative and CTL responses in vitro, whereas their T cells remain functionally normal. Our results reveal unexpected functions of 4-1BBL in the regulation of humoral immune responses and Ag presentation.

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