Genomic DNA Released by Dying Cells Induces the Maturation of APCs | Zendy

Ken J. Ishii | Zendy; Koichi Suzuki | Zendy; Cevayir Coban | Zendy; Fumihiko Takeshita | Zendy; Yasushi Itoh | Zendy; Hana Matoba | Zendy; Leonard D. Kohn | Zendy; Dennis M. Klinman | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Genomic DNA Released by Dying Cells Induces the Maturation of APCs

Author(s) -

Ken J. Ishii,

Koichi Suzuki,

Cevayir Coban,

Fumihiko Takeshita,

Yasushi Itoh,

Hana Matoba,

Leonard D. Kohn,

Dennis M. Klinman

Publication year - 2001

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.167.5.2602

Subject(s) - biology , immune system , dna , microbiology and biotechnology , antigen presenting cell , mhc class i , antigen presentation , genomic dna , major histocompatibility complex , t cell , immunology , genetics

Mature APCs play a key role in the induction of Ag-specific immunity. This work examines whether genomic DNA released by dying cells provides a stimulus for APC maturation. Double-stranded but not single-stranded genomic DNA triggered APC to up-regulate expression of MHC class I/II and various costimulatory molecules. Functionally, dsDNA enhanced APC function in vitro and improved primary cellular and humoral immune responses in vivo. These effects were dependent on the length and concentration of the dsDNA but were independent of nucleotide sequence. The maturation of APC induced by dsDNA may promote host survival by improving immune surveillance at sites of tissue injury/infection.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research