Open AccessSignaling Lymphocytic Activation Molecule Is Expressed on Mature CD83+ Dendritic Cells and Is Up-Regulated by IL-1β
Author(s) -
Monika Kruse,
Edgar Meinl,
Golo Henning,
Christine Kuhnt,
Susanne Berchtold,
Thomas G. Berger,
Gerold Schuler,
Alexander Steinkasserer
Publication year - 2001
Publication title -
the journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.737
H-Index - 372
eISSN - 1550-6606
pISSN - 0022-1767
DOI - 10.4049/jimmunol.167.4.1989
Subject(s) - microbiology and biotechnology , cd28 , measles virus , dendritic cell , cd40 , biology , receptor , chemistry , t cell , immunology , antigen , immune system , in vitro , cytotoxic t cell , biochemistry , measles , vaccination
Signaling lymphocyte activation molecule (SLAM), a 70-kDa costimulatory molecule that mediates CD28-independent proliferation of T cells and IFN-gamma production, has been identified on human T cells, immature thymocytes, and a subset of B cells. We have found that SLAM is expressed on mature but not immature dendritic cells (DC). However, the SLAM-associated protein, is missing in DC. SLAM surface expression is strongly up-regulated by IL-1beta. Addition of IL-1beta to the DC maturation mixture also increases the stimulatory properties of DC. These findings provide a new marker for DC maturation and help to explain two areas of DC biology. First, SLAM is a receptor for the measles virus, previously shown to infect DC. Second, SLAM could possibly contribute to the enhanced immunostimulatory functions of DC that are observed following the addition of IL-1.
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