Cutting Edge: The Common γ-Chain Is an Indispensable Subunit of the IL-21 Receptor Complex | Zendy

Hironobu Asao | Zendy; Chikara Okuyama | Zendy; Satoru Kumaki | Zendy; Naoto Ishii | Zendy; Shigeru Tsuchiya | Zendy; Don Foster | Zendy; Kazuo Sugamura | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Cutting Edge: The Common γ-Chain Is an Indispensable Subunit of the IL-21 Receptor Complex

Author(s) -

Hironobu Asao,

Chikara Okuyama,

Satoru Kumaki,

Naoto Ishii,

Shigeru Tsuchiya,

Don Foster,

Kazuo Sugamura

Publication year - 2001

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.167.1.1

Subject(s) - gamma subunit , interleukin 10 receptor, alpha subunit , common gamma chain , protein subunit , transfection , receptor , microbiology and biotechnology , biology , chemistry , cell culture , g alpha subunit , interleukin 21 receptor , gene , biochemistry , genetics

The common gamma-chain (gamma(c)) is an indispensable subunit of the functional receptor complexes for IL-4, IL-7, IL-9, and IL-15 as well as IL-2. Here we show that the gamma(c) is also shared with the IL-21R complex. Although IL-21 binds to the IL-21R expressed on gamma(c)-deficient ED40515(-) cells, IL-21 is unable to transduce any intracytoplasmic signals. However, in EDgamma-16 cells, a gamma(c)-transfected ED40515(-) cell line, IL-21 binds to the IL-21R and can activate Janus kinase (JAK)1, JAK3, STAT1, and STAT3. The chemical cross-linking study reveals the direct binding of IL-21 to the gamma(c). These data clearly demonstrate that the gamma(c) is an indispensable subunit of the functional IL-21R complex.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research