Expression of Stromal-Derived Factor-1 Is Decreased by IL-1 and TNF and in Dermal Wound Healing | Zendy

Eric R. Fedyk | Zendy; Dan Jones | Zendy; Hilary Critchley | Zendy; Richard P. Phipps | Zendy; Timothy M. Blieden | Zendy; Timothy A. Springer | Zendy

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Expression of Stromal-Derived Factor-1 Is Decreased by IL-1 and TNF and in Dermal Wound Healing

Author(s) -

Eric R. Fedyk,

Dan Jones,

Hilary Critchley,

Richard P. Phipps,

Timothy M. Blieden,

Timothy A. Springer

Publication year - 2001

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.166.9.5749

Subject(s) - stromal cell , wound healing , tumor necrosis factor alpha , medicine , immunology , cancer research

Stromal-derived factor-1 (SDF-1) is a CXC chemokine that is believed to be constitutively expressed by stromal cells of numerous tissues. In this report, we demonstrate that dermal fibroblasts and vessels of noninflamed tissues express SDF-1. Unexpectedly, we found that expression of SDF-1 is regulated by inflammation. Expression of SDF-1 by primary cultures of human gingival fibroblasts is potently inhibited by activated macrophages via secretion of IL-1alpha and TNF-alpha. Levels of SDF-1 mRNA also decrease in acutely inflamed mouse dermal wounds. We propose that SDF-1 functions as a homeostatic regulator of tissue remodeling, whose expression stabilizes existing dermal architecture.

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