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Activation of V gamma 9/V delta 2 T cells by small nonprotein Ags is frequently observed after infection with various viruses, bacteria, and eukaryotic parasites. We suggested earlier that compounds synthesized by the 2-C:-methyl-D-erythritol 4-phosphate (MEP) pathway of isopentenyl pyrophosphate synthesis are responsible for the V gamma 9/V delta 2 T cell reactivity of many pathogens. Using genetically engineered Escherichia coli knockout strains, we now demonstrate that the ability of E. coli extracts to stimulate gamma delta T cell proliferation is abrogated when genes coding for essential enzymes of the MEP pathway, dxr or gcpE, are disrupted or deleted from the bacterial genome.

the journal of immunology/the journal of immunology

Cutting Edge: Human γδ T Cells Are Activated by Intermediates of the 2-<i>C</i>-methyl-<scp>d</scp>-erythritol 4-phosphate Pathway of Isoprenoid Biosynthesis

Cutting Edge: Human γδ T Cells Are Activated by Intermediates of the 2-C-methyl-d-erythritol 4-phosphate Pathway of Isoprenoid Biosynthesis