Clonal Characterization of a Bipotent T Cell and NK Cell Progenitor in the Mouse Fetal Thymus | Zendy

Alison M. Michie | Zendy; James R. Carlyle | Zendy; Thomas M. Schmitt | Zendy; Belma Ljutic | Zendy; Sarah K. Cho | Zendy; Quyen Fong | Zendy; Juan Carlos ZúñigaPflücker | Zendy

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Clonal Characterization of a Bipotent T Cell and NK Cell Progenitor in the Mouse Fetal Thymus

Author(s) -

Alison M. Michie,

James R. Carlyle,

Thomas M. Schmitt,

Belma Ljutic,

Sarah K. Cho,

Quyen Fong,

Juan Carlos ZúñigaPflücker

Publication year - 2000

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.164.4.1730

Subject(s) - progenitor cell , microbiology and biotechnology , biology , progenitor , cell , population , immunology , t cell , phenotype , stem cell , genetics , immune system , medicine , gene , environmental health

We recently described a population of fetal thymocytes with a CD117+NK1.1+CD90lowCD25- phenotype, which were shown to contain committed T cell and NK cell progenitors. However, the characterization of a single cell with a restricted T and NK cell precursor potential was lacking. Here, using an in vitro model for T and NK cell differentiation, we provide conclusive evidence demonstrating the existence of a clonal lineage-restricted T and NK cell progenitor. These results establish that fetal thymocytes with a CD117+NK1.1+CD90lowCD25- phenotype represent bipotent T and NK cell progenitors.

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