Cutting Edge: A Dual TLR2 and TLR7 Ligand Induces Highly Potent Humoral and Cell-Mediated Immune Responses | Zendy

Alice Gutjahr | Zendy; Laura Papagno | Zendy; Francesco Nicoli | Zendy; Alain Lamoureux | Zendy; Fabienne Vernejoul | Zendy; Thierry Lioux | Zendy; Emma Gostick | Zendy; David A. Price | Zendy; Gérard Tiraby | Zendy; Éric Pérouzel | Zendy; Victor Appay | Zendy; Bernard Verrier | Zendy; Stéphane Paul | Zendy

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Cutting Edge: A Dual TLR2 and TLR7 Ligand Induces Highly Potent Humoral and Cell-Mediated Immune Responses

Author(s) -

Alice Gutjahr,

Laura Papagno,

Francesco Nicoli,

Alain Lamoureux,

Fabienne Vernejoul,

Thierry Lioux,

Emma Gostick,

David A. Price,

Gérard Tiraby,

Éric Pérouzel,

Victor Appay,

Bernard Verrier,

Stéphane Paul

Publication year - 2017

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.1602131

Subject(s) - tlr7 , tlr2 , immune system , dual (grammatical number) , ligand (biochemistry) , enhanced data rates for gsm evolution , microbiology and biotechnology , immunology , biology , chemistry , receptor , toll like receptor , innate immune system , genetics , computer science , art , literature , telecommunications

TLR agonists are currently being developed and tested as adjuvants in various formulations to optimize the immunogenicity and efficacy of vaccines. The aim of this study was to evaluate the immunostimulatory properties of a novel compound incorporating covalently linked moieties designed to stimulate both TLR2 and TLR7. This dual TLR2/TLR7 agonist induced the maturation of dendritic cells and primed substantial populations of cytolytic and highly polyfunctional effector CD8 + T cells in vitro, and safely potentiated the immunogenic properties of a nanoparticulate Ag in vivo, eliciting humoral responses with a balanced T H 1/T H 2 profile in mice. Collectively, these data reveal the potential utility of chimeric adjuvants with synergistic activities mediated via TLRs.

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