IL-17A–Induced PLET1 Expression Contributes to Tissue Repair and Colon Tumorigenesis | Zendy

Jarod A. Zepp | Zendy; Junjie Zhao | Zendy; Caini Liu | Zendy; Katazyna Bulek | Zendy; Ling Wu | Zendy; Xing Chen | Zendy; Yujun Hao | Zendy; Zhenghe Wang | Zendy; Xinxin Wang | Zendy; Wenjun Ouyang | Zendy; Matthew F. Kalady | Zendy; Julie Carman | Zendy; Wen-Pin Yang | Zendy; Jun Zhu | Zendy; Clare Blackburn | Zendy; Yina H. Huang | Zendy; Thomas A. Hamilton | Zendy; Bing Su | Zendy; Xiaoxia Li | Zendy

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IL-17A–Induced PLET1 Expression Contributes to Tissue Repair and Colon Tumorigenesis

Author(s) -

Jarod A. Zepp,

Junjie Zhao,

Caini Liu,

Katazyna Bulek,

Ling Wu,

Xing Chen,

Yujun Hao,

Zhenghe Wang,

Xinxin Wang,

Wenjun Ouyang,

Matthew F. Kalady,

Julie Carman,

Wen-Pin Yang,

Jun Zhu,

Clare Blackburn,

Yina H. Huang,

Thomas A. Hamilton,

Bing Su,

Xiaoxia Li

Publication year - 2017

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.1601540

Subject(s) - carcinogenesis , tissue repair , cancer research , colorectal cancer , biology , medicine , microbiology and biotechnology , cancer , genetics

This study identifies a novel mechanism linking IL-17A with colon tissue repair and tumor development. Abrogation of IL-17A signaling in mice attenuated tissue repair of dextran sulfate sodium (DSS)-induced damage in colon epithelium and markedly reduced tumor development in an azoxymethane/DSS model of colitis-associated cancer. A novel IL-17A target gene, PLET1 (a progenitor cell marker involved in wound healing), was highly induced in DSS-treated colon tissues and tumors in an IL-17RC-dependent manner. PLET1 expression was induced in LGR5 + colon epithelial cells after DSS treatment. LGR5 + PLET1 + marks a highly proliferative cell population with enhanced expression of IL-17A target genes. PLET1 deficiency impaired tissue repair of DSS-induced damage in colon epithelium and reduced tumor formation in an azoxymethane/DSS model of colitis-associated cancer. Our results suggest that IL-17A-induced PLET1 expression contributes to tissue repair and colon tumorigenesis.

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