Cutting Edge: IL-4, IL-21, and IFN-γ Interact To Govern T-bet and CD11c Expression in TLR-Activated B Cells | Zendy

Martin S. Naradikian | Zendy; Arpita Myles | Zendy; Daniel P. Beiting | Zendy; Kenneth J Roberts | Zendy; Lucas Dawson | Zendy; Ramin S. Herati | Zendy; Bertram Bengsch | Zendy; Susanne L. Linderman | Zendy; Erietta Stelekati | Zendy; Rosanne Spolski | Zendy; E. John Wherry | Zendy; Christopher A. Hunter | Zendy; Scott E. Hensley | Zendy; Warren J. Leonard | Zendy; Michael P. Cancro | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Cutting Edge: IL-4, IL-21, and IFN-γ Interact To Govern T-bet and CD11c Expression in TLR-Activated B Cells

Author(s) -

Martin S. Naradikian,

Arpita Myles,

Daniel P. Beiting,

Kenneth J Roberts,

Lucas Dawson,

Ramin S. Herati,

Bertram Bengsch,

Susanne L. Linderman,

Erietta Stelekati,

Rosanne Spolski,

E. John Wherry,

Christopher A. Hunter,

Scott E. Hensley,

Warren J. Leonard,

Michael P. Cancro

Publication year - 2016

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.1600522

Subject(s) - cd11c , expression (computer science) , enhanced data rates for gsm evolution , microbiology and biotechnology , biology , computer science , phenotype , telecommunications , genetics , gene , programming language

T-bet and CD11c expression in B cells is linked with IgG2c isotype switching, virus-specific immune responses, and humoral autoimmunity. However, the activation requisites and regulatory cues governing T-bet and CD11c expression in B cells remain poorly defined. In this article, we reveal a relationship among TLR engagement, IL-4, IL-21, and IFN-γ that regulates T-bet expression in B cells. We find that IL-21 or IFN-γ directly promote T-bet expression in the context of TLR engagement. Further, IL-4 antagonizes T-bet induction. Finally, IL-21, but not IFN-γ, promotes CD11c expression independent of T-bet. Using influenza virus and Heligmosomoides polygyrus infections, we show that these interactions function in vivo to determine whether T-bet(+) and CD11c(+) B cells are formed. These findings suggest that T-bet(+) B cells seen in health and disease share the common initiating features of TLR-driven activation within this circumscribed cytokine milieu.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research