LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation | Zendy

Alba Llibre | Zendy; Constantino LópezMacías | Zendy; Teresa Marafioti | Zendy; Hema Mehta | Zendy; Amy Partridge | Zendy; Carina Kanzig | Zendy; Felice Rivellese | Zendy; Jacob D. Galson | Zendy; L J Walker | Zendy; Paul Milne | Zendy; Rodney E. Phillips | Zendy; Dominic F. Kelly | Zendy; Gordon J. Freeman | Zendy; Mohey Eldin El Shikh | Zendy; Paul Klenerman | Zendy; Christian B. Willberg | Zendy

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LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation

Author(s) -

Alba Llibre,

Constantino LópezMacías,

Teresa Marafioti,

Hema Mehta,

Amy Partridge,

Carina Kanzig,

Felice Rivellese,

Jacob D. Galson,

L J Walker,

Paul Milne,

Rodney E. Phillips,

Dominic F. Kelly,

Gordon J. Freeman,

Mohey Eldin El Shikh,

Paul Klenerman,

Christian B. Willberg

Publication year - 2016

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.1502462

Subject(s) - downregulation and upregulation , germinal center , microbiology and biotechnology , cxcr4 , expression (computer science) , biology , b cell , immunology , computer science , genetics , gene , antibody , immune system , chemokine , programming language

Germinal centers (GCs) are microanatomical structures critical for the development of high-affinity Abs and B cell memory. They are organized into two zones, light and dark, with coordinated roles, controlled by local signaling. The innate lectin-like transcript 1 (LLT1) is known to be expressed on B cells, but its functional role in the GC reaction has not been explored. In this study, we report high expression of LLT1 on GC-associated B cells, early plasmablasts, and GC-derived lymphomas. LLT1 expression was readily induced via BCR, CD40, and CpG stimulation on B cells. Unexpectedly, we found high expression of the LLT1 ligand, CD161, on follicular dendritic cells. Triggering of LLT1 supported B cell activation, CD83 upregulation, and CXCR4 downregulation. Overall, these data suggest that LLT1-CD161 interactions play a novel and important role in B cell maturation within the GC in humans.

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