APOBEC3 Proteins in Viral Immunity | Zendy

Spyridon Stavrou | Zendy; Susan R. Ross | Zendy

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APOBEC3 Proteins in Viral Immunity

Author(s) -

Spyridon Stavrou,

Susan R. Ross

Publication year - 2015

Publication title -

the journal of immunology

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.1501504

Subject(s) - biology , intrinsic immunity , virology , innate immune system , acquired immune system , immunity , virus , cytidine deaminase , retrotransposon , immune system , genetics , dna , genome , gene , transposable element

Apolipoprotein B editing complex 3 family members are cytidine deaminases that play important roles in intrinsic responses to infection by retroviruses and have been implicated in the control of other viruses, such as parvoviruses, herpesviruses, papillomaviruses, hepatitis B virus, and retrotransposons. Although their direct effect on modification of viral DNA has been clearly demonstrated, whether they play additional roles in innate and adaptive immunity to viruses is less clear. We review the data regarding the various steps in the innate and adaptive immune response to virus infection in which apolipoprotein B editing complex 3 proteins have been implicated.

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