Open AccessCitrullination: A Specific Target for the Autoimmune Response in Rheumatoid Arthritis
Author(s) -
David A. Fox
Publication year - 2015
Publication title -
the journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.737
H-Index - 372
eISSN - 1550-6606
pISSN - 0022-1767
DOI - 10.4049/jimmunol.1501021
Subject(s) - citrullination , rheumatoid arthritis , medicine , immunology , citrulline , chemistry , biochemistry , arginine , amino acid
Rheumatoid arthritis (RA) was one of the first diseases to be classified as autoimmune, based on the prevalence of an autoantibody, rheumatoid factor, which was first identified in the 1940s. However, the diagnostic value and pathogenic significance of rheumatoid factor have been constrained by its
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