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Rheumatoid arthritis (RA) was one of the first diseases to be classified as autoimmune, based on the prevalence of an autoantibody, rheumatoid factor, which was first identified in the 1940s. However, the diagnostic value and pathogenic significance of rheumatoid factor have been constrained by its

Citrullination: A Specific Target for the Autoimmune Response in Rheumatoid Arthritis