Cutting Edge: Drebrin-Regulated Actin Dynamics Regulate IgE-Dependent Mast Cell Activation and Allergic Responses | Zendy

Mankit Law | Zendy; Yong Chan Lee | Zendy; José L. Quiles | Zendy; Gang Ning | Zendy; Weishan Huang | Zendy; Jonathan Pabón | Zendy; Arun Kannan | Zendy; AhReum Jeong | Zendy; Amie Wood | Zendy; Chavez Carter | Zendy; Sonia Mohinta | Zendy; Jihong Song | Zendy; Avery August | Zendy

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Cutting Edge: Drebrin-Regulated Actin Dynamics Regulate IgE-Dependent Mast Cell Activation and Allergic Responses

Author(s) -

Mankit Law,

Yong Chan Lee,

José L. Quiles,

Gang Ning,

Weishan Huang,

Jonathan Pabón,

Arun Kannan,

AhReum Jeong,

Amie Wood,

Chavez Carter,

Sonia Mohinta,

Jihong Song,

Avery August

Publication year - 2015

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.1401442

Subject(s) - degranulation , microbiology and biotechnology , actin , immunoglobulin e , mast cell , actin cytoskeleton , cytoskeleton , histamine , chemistry , calcium , biology , cell , immunology , antibody , receptor , biochemistry , endocrinology , organic chemistry

Mast cells play critical roles in allergic responses. Calcium signaling controls the function of these cells, and a role for actin in regulating calcium influx into cells has been suggested. We have previously identified the actin reorganizing protein Drebrin as a target of the immunosuppressant 3,5-bistrifluoromethyl pyrazole, which inhibits calcium influx into cells. In this study, we show that Drebrin(-/-) mice exhibit reduced IgE-mediated histamine release and passive systemic anaphylaxis, and Drebrin(-/-) mast cells also exhibit defects in FcεRI-mediated degranulation. Drebrin(-/-) mast cells exhibit defects in actin cytoskeleton organization and calcium responses downstream of the FcεRI, and agents that relieve actin reorganization rescue mast cell FcεRI-induced degranulation. Our results indicate that Drebrin regulates the actin cytoskeleton and calcium responses in mast cells, thus regulating mast cell function in vivo.

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