Granzymes Regulate Proinflammatory Cytokine Responses | Zendy

Annette C. Wensink | Zendy; C. Erik Hack | Zendy; Niels Bovenschen | Zendy

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Granzymes Regulate Proinflammatory Cytokine Responses

Author(s) -

Annette C. Wensink,

C. Erik Hack,

Niels Bovenschen

Publication year - 2015

Publication title -

the journal of immunology

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.1401214

Subject(s) - granzyme , cytotoxic t cell , proteases , inflammation , proinflammatory cytokine , granzyme b , immunology , immune system , granzyme a , cytokine , biology , microbiology and biotechnology , t cell , perforin , cd8 , biochemistry , enzyme , in vitro

Granzymes (Grs) are serine proteases mainly produced by cytotoxic lymphocytes and are traditionally considered to cause apoptosis in tumor cells and virally infected cells. However, the cytotoxicity of several Grs is currently being debated, and additional, predominantly extracellular, functions of Grs in inflammation are emerging. Extracellular soluble Grs are elevated in the circulation of patients with autoimmune diseases and infections. Additionally, Grs are expressed by several types of immune cells other than cytotoxic lymphocytes. Recent research has revealed novel immunomodulatory functions of Grs. In this review, we provide a comprehensive overview on the role of Grs in inflammation, highlighting their role in cytokine induction and processing.

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