Open AccessAdipocyte IL-15 Regulates Local and Systemic NK Cell Development
Author(s) -
Yae-Huei Liou,
SzuWen Wang,
Chin-Ling Chang,
Po-Lin Huang,
Mau-Sheng Hou,
YeinGei Lai,
Gilbert Aaron Lee,
SiTse Jiang,
ChingYen Tsai,
NanShih Liao
Publication year - 2014
Publication title -
the journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.737
H-Index - 372
eISSN - 1550-6606
pISSN - 0022-1767
DOI - 10.4049/jimmunol.1400868
Subject(s) - adipose tissue , adipocyte , biology , adipose tissue macrophages , haematopoiesis , spleen , natural killer cell , microbiology and biotechnology , interleukin 15 , interleukin 12 , white adipose tissue , immunology , interleukin , stem cell , endocrinology , cytokine , cytotoxic t cell , in vitro , biochemistry
NK cell development and homeostasis require IL-15 produced by both hematopoietic and parenchymal cells. Certain hematopoietic IL-15 sources, such as macrophages and dendritic cells, are known, whereas the source of parenchymal IL-15 remains elusive. Using two types of adipocyte-specific Il15(-/-) mice, we identified adipocytes as a parenchymal IL-15 source that supported NK cell development nonredundantly. Both adipocyte-specific Il15(-/-) mice showed reduced IL-15 production specifically in the adipose tissue but impaired NK cell development in the spleen and liver in addition to the adipose tissue. We also found that the adipose tissue harbored NK progenitors as other niches (e.g. spleen) for NK cell development, and that NK cells derived from transplanted adipose tissue populated the recipient's spleen and liver. These findings suggest that adipocyte IL-15 contributes to systemic NK cell development by supporting NK cell development in the adipose tissue, which serves as a source of NK cells for other organs.
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