Human Hematopoietic Reconstitution and HLA-Restricted Responses in Nonpermissive Alymphoid Mice | Zendy

Malika Serra-Hassoun | Zendy; Maryline Bourgine | Zendy; Michele Boniotto | Zendy; Julien Berges | Zendy; Francina Langa | Zendy; MarieLouise Michel | Zendy; António A. Freitas | Zendy; Sylvie Garcia | Zendy

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Human Hematopoietic Reconstitution and HLA-Restricted Responses in Nonpermissive Alymphoid Mice

Author(s) -

Malika Serra-Hassoun,

Maryline Bourgine,

Michele Boniotto,

Julien Berges,

Francina Langa,

MarieLouise Michel,

António A. Freitas,

Sylvie Garcia

Publication year - 2014

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.1400412

Subject(s) - humanized mouse , biology , immune system , haematopoiesis , immunology , major histocompatibility complex , transgene , human leukocyte antigen , genetically modified mouse , virology , immunization , stem cell , microbiology and biotechnology , antigen , genetics , gene

We generated a new humanized mouse model to study HLA-restricted immune responses. For this purpose, we created unique murine hosts by enforcing the expression of human SIRPα by murine phagocytes in murine MHC-deficient HLA-transgenic alymphoid hosts, an approach that allowed the immune reconstitution of nonpermissive mice following injection of human hematopoietic stem cells. We showed that these mouse/human chimeras were able to generate HLA-restricted responses to immunization. These new humanized mice may offer attractive models to study immune responses to human diseases, such as HIV and EBV infections, as well as to assay new vaccine strategies.

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