PILRα Negatively Regulates Mouse Inflammatory Arthritis | Zendy

Yonglian Sun | Zendy; Patrick Caplazi | Zendy; Juan Zhang | Zendy; Anita Mazloom | Zendy; Sarah Kummerfeld | Zendy; Gabriel A. Quiñones | Zendy; Kate Senger | Zendy; Justin Lesch | Zendy; Ivan Peng | Zendy; Andrew Sebrell | Zendy; Wilman Luk | Zendy; Yanmei Lu | Zendy; Zhonghua Lin | Zendy; Kai Barck | Zendy; Judy Young | Zendy; Mariela Del Rio | Zendy; Sophie M. Lehar | Zendy; Vida Asghari | Zendy; WeiYu Lin | Zendy; Sanjeev Mariathasan | Zendy; Jason DeVoss | Zendy; Shahram Misaghi | Zendy; Mercedesz Balázs | Zendy; Tao Sai | Zendy; Benjamin Haley | Zendy; Philip E. Hass | Zendy; Min Xu | Zendy; Wenjun Ouyang | Zendy; Flavius Martin | Zendy; Wyne P. Lee | Zendy; Ali A. Zarrin | Zendy

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PILRα Negatively Regulates Mouse Inflammatory Arthritis

Author(s) -

Yonglian Sun,

Patrick Caplazi,

Juan Zhang,

Anita Mazloom,

Sarah Kummerfeld,

Gabriel A. Quiñones,

Kate Senger,

Justin Lesch,

Ivan Peng,

Andrew Sebrell,

Wilman Luk,

Yanmei Lu,

Zhonghua Lin,

Kai Barck,

Judy Young,

Mariela Del Rio,

Sophie M. Lehar,

Vida Asghari,

WeiYu Lin,

Sanjeev Mariathasan,

Jason DeVoss,

Shahram Misaghi,

Mercedesz Balázs,

Tao Sai,

Benjamin Haley,

Philip E. Hass,

Min Xu,

Wenjun Ouyang,

Flavius Martin,

Wyne P. Lee,

Ali A. Zarrin

Publication year - 2014

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.1400045

Subject(s) - arthritis , inflammatory arthritis , immunology , microbiology and biotechnology , biology

Paired Ig-like type 2 receptor (PILR)α inhibitory receptor and its counterpart PILRβ activating receptor are coexpressed on myeloid cells. In this article, we report that PILRα, but not PILRβ, is elevated in human rheumatoid arthritis synovial tissue and correlates with inflammatory cell infiltration. Pilrα(-/-) mice produce more pathogenic cytokines during inflammation and are prone to enhanced autoimmune arthritis. Correspondingly, engaging PILRα with anti-PILRα mAb ameliorates inflammation in mouse arthritis models and suppresses the production of proinflammatory cytokines. Our studies suggest that PILRα mediates an important inhibitory pathway that can dampen inflammatory responses.

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