Open AccessComment on “TLR9 Provokes Inflammation in Response to Fetal DNA: Mechanism for Fetal Loss in Preterm Birth and Preeclampsia”
Author(s) -
Colin L. Crawford
Publication year - 2013
Publication title -
the journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.737
H-Index - 372
eISSN - 1550-6606
pISSN - 0022-1767
DOI - 10.4049/jimmunol.1390031
Subject(s) - preeclampsia , fetus , mechanism (biology) , medicine , obstetrics , inflammation , tlr9 , pregnancy , biology , genetics , dna methylation , philosophy , gene , gene expression , epistemology
Scharfe-Nugent and colleagues ([1][1]) have suggested that the use of chloroquine may reduce the frequency of preterm births. The drug acts as a TLR9 inhibitor, reducing inflammation and the concentration of IL-6. Other TLR9 antagonists produce their effect by lowering the level of IFN-α ([2][2]),
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