MiR-210 Is Induced by Oct-2, Regulates B Cells, and Inhibits Autoantibody Production | Zendy

Yingting Mok | Zendy; Vera Schwierzeck | Zendy; David Thomas | Zendy; Elena Vigorito | Zendy; Tim F. Rayner | Zendy; Lorna B. Jarvis | Zendy; Haydn M. Prosser | Zendy; Allan Bradley | Zendy; David R. Withers | Zendy; IngaLill Mårtensson | Zendy; Lynn M. Corcoran | Zendy; Cherie Blenkiron | Zendy; Eric A. Miska | Zendy; Paul Lyons | Zendy; Kenneth G. C. Smith | Zendy

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MiR-210 Is Induced by Oct-2, Regulates B Cells, and Inhibits Autoantibody Production

Author(s) -

Yingting Mok,

Vera Schwierzeck,

David Thomas,

Elena Vigorito,

Tim F. Rayner,

Lorna B. Jarvis,

Haydn M. Prosser,

Allan Bradley,

David R. Withers,

IngaLill Mårtensson,

Lynn M. Corcoran,

Cherie Blenkiron,

Eric A. Miska,

Paul Lyons,

Kenneth G. C. Smith

Publication year - 2013

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.1301289

Subject(s) - downregulation and upregulation , autoantibody , microrna , microbiology and biotechnology , biology , transfection , transcriptome , gene , b cell , cell growth , in vitro , gene expression , regulation of gene expression , antibody , immunology , genetics

MicroRNAs (MiRs) are small, noncoding RNAs that regulate gene expression posttranscriptionally. In this study, we show that MiR-210 is induced by Oct-2, a key transcriptional mediator of B cell activation. Germline deletion of MiR-210 results in the development of autoantibodies from 5 mo of age. Overexpression of MiR-210 in vivo resulted in cell autonomous expansion of the B1 lineage and impaired fitness of B2 cells. Mice overexpressing MiR-210 exhibited impaired class-switched Ab responses, a finding confirmed in wild-type B cells transfected with a MiR-210 mimic. In vitro studies demonstrated defects in cellular proliferation and cell cycle entry, which were consistent with the transcriptomic analysis demonstrating downregulation of genes involved in cellular proliferation and B cell activation. These findings indicate that Oct-2 induction of MiR-210 provides a novel inhibitory mechanism for the control of B cells and autoantibody production.

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