IL-4 in the Brain: A Cytokine To Remember | Zendy

Sachin P. Gadani | Zendy; James C. Cronk | Zendy; Geoffrey T. Norris | Zendy; Jonathan Kipnis | Zendy

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IL-4 in the Brain: A Cytokine To Remember

Author(s) -

Sachin P. Gadani,

James C. Cronk,

Geoffrey T. Norris,

Jonathan Kipnis

Publication year - 2012

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.1202246

Subject(s) - neuroscience , context (archaeology) , brain function , cytokine , psychology , cognitive science , function (biology) , immunology , biology , evolutionary biology , paleontology

IL-4 has been extensively studied in the context of its role in immunity. Accumulating evidence indicates, however, that it also plays a critical role in higher functions of the normal brain, such as memory and learning. In this review, we summarize current knowledge of the basic immunology of IL-4, describe how and where this cytokine appears to operate in normal brain function, and propose a hypothesis concerning its potential role in neurological pathologies.

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