Open AccessPositive Selection in the Thymus: An Enigma Wrapped in a Mystery
Author(s) -
Stephen Μ. Hedrick
Publication year - 2012
Publication title -
the journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.737
H-Index - 372
eISSN - 1550-6606
pISSN - 0022-1767
DOI - 10.4049/jimmunol.1200077
Subject(s) - selection (genetic algorithm) , biology , immunology , computer science , artificial intelligence
One of the many mysteries that loomed over the field of immunology in its dark ages (that period prior to characterization of the TCR and peptide binding by MHC molecules) was the process of T cell development and selection of the receptor repertoire in the thymus. The work of Hogquist and
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