Cutting Edge: Expression of XCR1 Defines Mouse Lymphoid-Tissue Resident and Migratory Dendritic Cells of the CD8α+ Type | Zendy

Karine Crozat | Zendy; Samira Tamoutounour | Zendy; ThienPhong Vu Manh | Zendy; Even Fossum | Zendy; Hervé Luche | Zendy; Laurence Ardouin | Zendy; Martin Guilliams | Zendy; Hiroaki Azukizawa | Zendy; Bjarne Bogen | Zendy; Bernard Malissen | Zendy; Sandrine Henri | Zendy; Marc Dalod | Zendy

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Cutting Edge: Expression of XCR1 Defines Mouse Lymphoid-Tissue Resident and Migratory Dendritic Cells of the CD8α+ Type

Author(s) -

Karine Crozat,

Samira Tamoutounour,

ThienPhong Vu Manh,

Even Fossum,

Hervé Luche,

Laurence Ardouin,

Martin Guilliams,

Hiroaki Azukizawa,

Bjarne Bogen,

Bernard Malissen,

Sandrine Henri,

Marc Dalod

Publication year - 2011

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.1101717

Subject(s) - spleen , cd8 , cross presentation , biology , dendritic cell , immunology , microbiology and biotechnology , lymphatic system , follicular dendritic cells , antigen , immune system , t cell , antigen presenting cell , mhc class i

Subsets of dendritic cells (DCs) have been described according to their functions and anatomical locations. Conventional DC subsets are defined by reciprocal expression of CD11b and CD8α in lymphoid tissues (LT), and of CD11b and CD103 in non-LT (NLT). Spleen CD8α(+) and dermal CD103(+) DCs share a high efficiency for Ag cross-presentation and a developmental dependency on specific transcription factors. However, it is not known whether all NLT-derived CD103(+) DCs and LT-resident CD8α(+) DCs are similar despite their different anatomical locations. XCR1 was previously described as exclusively expressed on mouse spleen CD8α(+) DCs and human blood BDCA3(+) DCs. In this article, we showed that LT-resident CD8α(+) DCs and NLT-derived CD103(+) DCs specifically express XCR1 and are characterized by a unique transcriptional fingerprint, irrespective of their tissue of origin. Therefore, CD8α(+) DCs and CD103(+) DCs belong to a common DC subset which is unequivocally identified by XCR1 expression throughout the body.

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