B Lymphocyte Commitment Program Is Driven by the Proto-Oncogene c-myc | Zendy

Mireia Vallespinós | Zendy; David FernándezAntorán | Zendy; Lorena Rodríguez | Zendy; Josué Álvaro-Blanco | Zendy; Esther Baena | Zendy; Maitane Ortiz | Zendy; Daniela Dukovska | Zendy; Dolores Fernández Martínez | Zendy; Ana M. Rojas | Zendy; Miguel R. Campanero | Zendy; Ignacio Moreno de Alborán | Zendy

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B Lymphocyte Commitment Program Is Driven by the Proto-Oncogene c-myc

Author(s) -

Mireia Vallespinós,

David FernándezAntorán,

Lorena Rodríguez,

Josué Álvaro-Blanco,

Esther Baena,

Maitane Ortiz,

Daniela Dukovska,

Dolores Fernández Martínez,

Ana M. Rojas,

Miguel R. Campanero,

Ignacio Moreno de Alborán

Publication year - 2011

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.1002753

Subject(s) - transcription factor , biology , oncogene , b cell , cellular differentiation , gene , microbiology and biotechnology , transcription (linguistics) , lymphocyte , cell , genetics , cancer research , cell cycle , antibody , linguistics , philosophy

c-Myc, a member of the Myc family of transcription factors, is involved in numerous biological functions including the regulation of cell proliferation, differentiation, and apoptosis in various cell types. Of all of its functions, the role of c-Myc in cell differentiation is one of the least understood. We addressed the role of c-Myc in B lymphocyte differentiation. We found that c-Myc is essential from early stages of B lymphocyte differentiation in vivo and regulates this process by providing B cell identity via direct transcriptional regulation of the ebf-1 gene. Our data show that c-Myc influences early B lymphocyte differentiation by promoting activation of B cell identity genes, thus linking this transcription factor to the EBF-1/Pax-5 pathway.

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