CD8 Controls T Cell Cross-Reactivity | Zendy

Linda Wooldridge | Zendy; Bruno Laugel | Zendy; Julia Ekeruche | Zendy; Mathew Clement | Zendy; Hugo A. van den Berg | Zendy; David A. Price | Zendy; Andrew K. Sewell | Zendy

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CD8 Controls T Cell Cross-Reactivity

Author(s) -

Linda Wooldridge,

Bruno Laugel,

Julia Ekeruche,

Mathew Clement,

Hugo A. van den Berg,

David A. Price,

Andrew K. Sewell

Publication year - 2010

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.1001480

Subject(s) - t cell receptor , repertoire , t cell , biology , cd8 , receptor , cross reactivity , microbiology and biotechnology , antigen , major histocompatibility complex , reactivity (psychology) , immunology , cell , immune system , genetics , cross reactions , medicine , physics , alternative medicine , pathology , acoustics

Estimates of human αβ TCR diversity suggest that there are <10(8) different Ag receptors in the naive T cell pool, a number that is dwarfed by the potential number of different antigenic peptide-MHC (pMHC) molecules that could be encountered. Consequently, an extremely high degree of cross-reactivity is essential for effective T cell immunity. Ag recognition by T cells is unique in that it involves a coreceptor that binds at a site distinct from the TCR to facilitate productive engagement of the pMHC. In this study, we show that the CD8 coreceptor controls T cell cross-reactivity for pMHCI Ags, thereby ensuring that the peripheral T cell repertoire is optimally poised to negotiate the competing demands of responsiveness in the face of danger and quiescence in the presence of self.

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