Cutting Edge: KIR Antisense Transcripts Are Processed into a 28-Base PIWI-Like RNA in Human NK Cells | Zendy

Frank Cichocki | Zendy; Todd Lenvik | Zendy; Neeraj Sharma | Zendy; Gong Yun | Zendy; Stephen K. Anderson | Zendy; Jeffrey S. Miller | Zendy

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Cutting Edge: KIR Antisense Transcripts Are Processed into a 28-Base PIWI-Like RNA in Human NK Cells

Author(s) -

Frank Cichocki,

Todd Lenvik,

Neeraj Sharma,

Gong Yun,

Stephen K. Anderson,

Jeffrey S. Miller

Publication year - 2010

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.1000855

Subject(s) - piwi interacting rna , gene silencing , biology , rna silencing , antisense rna , transposable element , rasirna , argonaute , rna , gene , genetics , microbiology and biotechnology , rna interference , dna methylation , rna induced silencing complex , gene expression , genome

Killer Ig-like receptors (KIRs) are expressed in a variegated, clonally restricted fashion on NK cells and are important determinants of NK cell function. Although silencing of individual KIR genes is strongly correlated with the presence of CpG dinucleotide methylation within the promoter, the mechanism responsible for silencing has not been identified. Our results show that antisense transcripts mediate KIR transcriptional silencing through a novel PIWI-like 28-base small RNA. Although PIWI RNA-mediated silencing of transposable elements within germ cells have been described, this is the first report that identifies a PIWI-like RNA in an immune somatic cell lineage and identifies a mechanism that may be broadly used in orchestrating immune development.

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