Complement-Dependent Transport of Antigen into B Cell Follicles | Zendy

Santiago González | Zendy; Veronika LukacsKornek | Zendy; Michael Kuligowski | Zendy; Lisa A. Pitcher | Zendy; Søren E. Degn | Zendy; Shan J. Turley | Zendy; Michael C. Carroll | Zendy

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Complement-Dependent Transport of Antigen into B Cell Follicles

Author(s) -

Santiago González,

Veronika LukacsKornek,

Michael Kuligowski,

Lisa A. Pitcher,

Søren E. Degn,

Shan J. Turley,

Michael C. Carroll

Publication year - 2010

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.1000522

Subject(s) - antibody opsonization , complement receptor , complement system , classical complement pathway , biology , immunology , acquired immune system , opsonin , antigen , microbiology and biotechnology , immune system , antibody

Since the original proposal by Fearon and Locksley (Fearon and Locksley. 1996. Science 272: 50-53) that the complement system linked innate and adaptive immunity, there has been a rapid expansion of studies on this topic. With the advance of intravital imaging, a number of recent papers revealed an additional novel pathway in which complement C3 and its receptors enhance humoral immunity through delivery of Ag to the B cell compartment. In this review, we discuss this pathway and highlight several novel exceptions recently found with a model influenza vaccine, such as mannose-binding lectin opsonization of influenza and uptake by macrophages, and the capture of virus by dendritic cells residing in the medullary compartment of peripheral lymph nodes.

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