Open AccessPlugging the Leaky Pre-B Cell Receptor
Author(s) -
Mary Ellen Conley,
Peter D. Burrows
Publication year - 2010
Publication title -
the journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.737
H-Index - 372
eISSN - 1550-6606
pISSN - 0022-1767
DOI - 10.4049/jimmunol.0990113
Subject(s) - receptor , microbiology and biotechnology , biology , genetics
Although it is expressed very transiently and at very low cell surface density, the pre-BCR plays a critical role in early B cell development ([1][1], [2][2]). The proteins that are required to assemble the pre-BCR, the signal transduction molecules Igα and Igβ, and the components of the surrogate
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