Metabolic Shifts in Immunity and Inflammation | Zendy

Douglas J. Kominsky | Zendy; Eric L. Campbell | Zendy; Sean P. Colgan | Zendy

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Metabolic Shifts in Immunity and Inflammation

Author(s) -

Douglas J. Kominsky,

Eric L. Campbell,

Sean P. Colgan

Publication year - 2010

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.0903002

Subject(s) - inflammation , biology , immune system , immunity , hypoxia (environmental) , phenotype , immunology , metabolism , metabolic acidosis , cell metabolism , endocrinology , chemistry , biochemistry , oxygen , organic chemistry , gene

Sites of ongoing inflammation and triggered immune responses are characterized by significant changes in metabolic activity. Recent studies have indicated that such shifts in tissue metabolism result from a combination of profound recruitment of inflammatory cells (neutrophils and monocytes) and high proliferation rates among lymphocyte populations. The resultant shifts in energy supply and demand can result in metabolic acidosis and diminished delivery and/or availability of oxygen, leading to hypoxia extensive enough to trigger transcriptional and translation changes in tissue phenotype. Such phenotypic shifts can imprint fundamental changes to tissue metabolism. In this study, we review recent work addressing metabolic changes and metabolic control of inflammation and immunity.

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