Signal-Transducing Adaptor Protein-2 Regulates Stromal Cell-Derived Factor-1α-Induced Chemotaxis in T Cells | Zendy

Yuichi Sekine | Zendy; Osamu Ikeda | Zendy; Satoshi Tsuji | Zendy; Chikako Yamamoto | Zendy; Ryuta Muromoto | Zendy; Asuka Nanbo | Zendy; Kenji Oritani | Zendy; Akihiko Yoshimura | Zendy; Tadashi Matsuda | Zendy

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Signal-Transducing Adaptor Protein-2 Regulates Stromal Cell-Derived Factor-1α-Induced Chemotaxis in T Cells

Author(s) -

Yuichi Sekine,

Osamu Ikeda,

Satoshi Tsuji,

Chikako Yamamoto,

Ryuta Muromoto,

Asuka Nanbo,

Kenji Oritani,

Akihiko Yoshimura,

Tadashi Matsuda

Publication year - 2009

Publication title -

the journal of immunology

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.0902096

Subject(s) - signal transducing adaptor protein , jurkat cells , rac1 , guanine nucleotide exchange factor , microbiology and biotechnology , cdc42 , pleckstrin homology domain , chemotaxis , signal transduction , cell migration , stromal cell , biology , chemistry , t cell , cell , receptor , cancer research , biochemistry , immunology , immune system

Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that contains pleckstrin and Src homology 2-like domains, as well as a YXXQ motif in its C-terminal region. Our previous studies revealed that STAP-2 regulates integrin-mediated T cell adhesion. In the present study, we find that STAP-2 expression affects Jurkat T cell migration after stromal cell-derived factor-1alpha (SDF-1alpha)-treatment. Furthermore, STAP-2-deficient T cells exhibit reduced cell migration after SDF-1alpha-treatment. Importantly, overexpression of STAP-2 in Jurkat T cells induces activation of small guanine triphosphatases, such as Rac1 and Cdc42. Regarding the mechanism for this effect, we found that STAP-2 associates with Vav1, the guanine-nucleotide exchanging factor for Rac1, and enhances downstream Vav1/Rac1 signaling. These results reveal a novel STAP-2-mediated mechanism for the regulation of SDF-1alpha-induced chemotaxis of T cells via activation of Vav1/Rac1 signaling.

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